What is it about?
A tool to detect endogenous Rho activity revealed active RhoA at the leading edge of migrating cells to control mDia1 for polarity and formation of stable, oriented microtubules downstream of G12/G13 proteins.
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Why is it important?
First demonstration of leading edge Rho activity on endogenous Rho, previously thought to act primarily at the trailing edge of migrating cells.
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This page is a summary of: G 12/13 Is Essential for Directed Cell Migration and Localized Rho-Dia1 Function, Journal of Biological Chemistry, October 2005, American Society for Biochemistry & Molecular Biology (ASBMB),
DOI: 10.1074/jbc.m508690200.
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