What is it about?
Thymosin β4 promotes skin and corneal wound healing . This 43-amino acid peptide strongly activates endothelial cells to express and release plasminogen activator inhibitor type 1 (PAI-1). We show that Tβ4 up-regulates expression and induces the surface accumulation of α1-acid glycoprotein (AGP) known to bind PAI-1 and prolong its inhibitory activity.
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Why is it important?
A novel mechanism by which active PAI-1 can be bound to the Tβ4 activated endothelial cells, thus influencing their adhesive properties as well as their ability to generate plasmin
Perspectives
The present results may indicate that a normally endogenous protein such as Tβ4 - expressed in all types of cells - may be re-deployed to protect endothelium, for example, in the setting of acute inflammation events.
Professor Elzbieta Wyroba
Nencki Institute of Experimental Biology
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This page is a summary of: Binding of PAI-1 to Endothelial Cells Stimulated by Thymosin β4 and Modulation of Their Fibrinolytic Potential, Journal of Biological Chemistry, November 2005, American Society for Biochemistry & Molecular Biology (ASBMB),
DOI: 10.1074/jbc.m506303200.
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