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We identify Thr29 as the main phosphorylation site on the proton channel. Phosphorylating this site on the intracellular N terminus appears to convert the channel into the "enhanced gating mode."
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This page is a summary of: Identification of Thr29 as a Critical Phosphorylation Site That Activates the Human Proton Channel Hvcn1 in Leukocytes, Journal of Biological Chemistry, December 2009, American Society for Biochemistry & Molecular Biology (ASBMB),
DOI: 10.1074/jbc.c109.082727.
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