The gp91phox Component of NADPH Oxidase Is Not the Voltage-gated Proton Channel in Phagocytes, but It Helps

What is it about?

Identical proton currents are found in control PLB-985 cells, gp91phox knock-outs (and re-transfectants) and in human CGD phagocytes that lack gp91phox expression. Furthermore, stimulation with PMA increases the proton conductance identically in all cells. Therefore, gp91phox is not a proton channel in phagocytes.

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Why is it important?

We were amazed when we had published what we thought was definitive and incontrovertible proof that gp91phox is not a proton channel, but most of the field refused to accept this!