What is it about?
Nitric oxide has many important biological functions but others are still being discovered. This paper shows that nitric oxide made by living cells triggers them to quickly reallocate a special form of their iron called heme. The heme reallocation causes the cells to assemble their nitric oxide receptor protein and this amplifies cellular signaling in a new way.
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Why is it important?
That physiologic levels of nitric oxide can influence heme allocation within cells is unexpected and uncovers a new way that nitric oxide naturally helps to maintain proper functioning in our cells and tissues. It also suggests a new strategy we could utilize for improving their function in disease.
Perspectives
Using nitric oxide to control heme allocation is likely to be a widely adapted natural strategy in biology.
Dennis Stuehr Stuehr
Cleveland Clinic
Read the Original
This page is a summary of: NO rapidly mobilizes cellular heme to trigger assembly of its own receptor, Proceedings of the National Academy of Sciences, January 2022, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2115774119.
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