A pH-stabilizing role of voltage-gated proton channels in IgE-mediated activation of human basophils

What is it about?

Proton channels in human basophils exhibit enhanced gating when stimulated with secretagogues, PMA or anti-IgE. Inhibition of histamine release by Zn2+ suggests a role for proton channel activity. This idea is supported by demonstration that Zn2+ also enhances the cytoplasmic acidification that occurs upon stimulation with anti-IgE.

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