What is it about?
EMT (epithelial-mesenchymal transition) is a biological process by which a cell loses its usual characteristics and acquires properties that enable it to move. Essential for embryonic development and tissue repair, EMT is also involved in the formation of fibrosis or metastases. In an article published in PNAS, scientists have highlighted the importance of translation and ribosome plasticity in this process.
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Why is it important?
This work demonstrates the importance of ribosome reprogramming, and translation fidelity, in cell state changes, potentially presenting new therapeutic avenues to combat the onset of metastasis.
Perspectives
In addition to cancer, these data might have an impact on EMT-related pathological processes, such as developmental defects, fibrosis or cancer.
Virginie Marcel
Cancer Research Center of Lyon
Read the Original
This page is a summary of: Intricate ribosome composition and translational reprogramming in epithelial–mesenchymal transition, Proceedings of the National Academy of Sciences, December 2024, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2408114121.
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