Hepatocyte regeneration is driven by embryo-like DNA methylation reprogramming

What is it about?

This paper sheds light on liver regeneration following partial hepatectomy by showing that this process requires programmed changes in DNA methylation that bring about partial dedifferentiation to proliferating progenitor cells no longer present in the adult liver. The identification of this previously unknown pathway suggests that even tissues lacking adult stem cells may be amenable to embryonic reprogramming to create a progenitor state capable of regenerating normal tissue following injury or diseases, such as neurodegeneration or diabetes.

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Why is it important?

This paper reveals new insights into how stemless tissue can regenerate, opening up new strategies for regenerative medicine.