What is it about?

Development of an inducible transcription factor for ex vivo expansion of human CD34+ progenitor cells. This method allows the generation and massive expansion of late monocytic progenitors. Upon transcription factor switch off and differentiation fully functional macrophages were obtained.

Featured Image

Why is it important?

With a single factor/gene we could produce large amounts of functional immune cells in short time.

Perspectives

With other leukemia associated transcription factors we aim to establish other blood cell types.

Christian Wichmann
Ludwig-Maximilians-Universitat Munchen

Read the Original

This page is a summary of: Engineering an inducible leukemia-associated fusion protein enables large-scale ex vivo production of functional human phagocytes, Proceedings of the National Academy of Sciences, June 2024, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2312499121.
You can read the full text:

Read

Contributors

The following have contributed to this page