What is it about?

Development of an inducible transcription factor for ex vivo expansion of human CD34+ progenitor cells. This method allows the generation and massive expansion of late monocytic progenitors. Upon transcription factor switch off and differentiation fully functional macrophages were obtained.

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Why is it important?

With a single factor/gene we could produce large amounts of functional immune cells in short time.


With other leukemia associated transcription factors we aim to establish other blood cell types.

Christian Wichmann
Ludwig-Maximilians-Universitat Munchen

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This page is a summary of: Engineering an inducible leukemia-associated fusion protein enables large-scale ex vivo production of functional human phagocytes, Proceedings of the National Academy of Sciences, June 2024, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2312499121.
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