What is it about?
The focus of this research was to explore the biological activity of thiomorpholino oligonucleotides-a new oligonucleotides analogue. We observed that this analogue was more biologically active than any other explored chemistry.
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Why is it important?
The research is important as many oligonucleotide analogues are being examined for biological activity and current analogues have certain limitations. These observations suggest that new analogues such as the thiomorpholino derivatives as discussed here, should be thoroughly examined.
Perspectives
We are quite excited about the results so far obtained in approximately 25 biological systems, including the research outlined in this manuscript, and continue to investigate the possible implications of our research.
Marvin Caruthers
University of Colorado
Read the Original
This page is a summary of: Thiomorpholino oligonucleotides as a robust class of next generation platforms for alternate mRNA splicing, Proceedings of the National Academy of Sciences, August 2022, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2207956119.
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