What is it about?
Coenzyme M is the smallest known organic cofactor and is most commonly associated with the methane-forming step in all methanogenic archaea. It has also been found in a small number of bacteria capable of the metabolism of small organics. Although many of the steps for CoM biosynthesis in methanogenic archaea have been elucidated, a complete pathway for the biosynthesis of CoM in archaea or bacteria has not been reported. In this paper, we have elucidated the complete coenzyme M biosynthesis pathway in bacteria, revealing distinct chemical steps relative to CoM biosynthesis in methanogenic archaea. The existence of different pathways represents a profound instance of convergent evolution.
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Why is it important?
We have elucidated the completer pathway for coenzyme M biosynthesis in bacteria occurs by a suite of activities that are distinct from those involved in coenzyme M biosynthesis in methanogenic archaea thereby indicating that biosynthesis of this cofactor in bacteria and archaea evolved independently. In bacteria, coenzyme M biosynthesis pathway reveals new reactivities for known enzyme families.
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This page is a summary of: The pathway for coenzyme M biosynthesis in bacteria, Proceedings of the National Academy of Sciences, August 2022, Proceedings of the National Academy of Sciences, DOI: 10.1073/pnas.2207190119.
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