What is it about?
B cells develop in the bone marrow. However, some B cells may recognize self-antigens and could potentially produce autoantibodies and cause autoimmune diseases. Such autoreactive B cells need to be eliminated at the immature B cell stage. This paper identified a new mechanism that contributes to the elimination of autorective immature B cells.
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Why is it important?
Millions of people suffer from various autoimmune diseases such as rheumatoid arthritis. It is therefore important to understand the mechanism by which autoreactive B cells are eliminated.
Perspectives
This study could potentially help with the disgnosis and treatment of various autoimmune diseases in the future.
Ji-Yang Wang
Read the Original
This page is a summary of: LAPTM5 mediates immature B cell apoptosis and B cell tolerance by regulating the WWP2-PTEN-AKT pathway, Proceedings of the National Academy of Sciences, August 2022, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2205629119.
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