What is it about?

Oligodendrocytes precursor cells(OPCs) in the brain and known to produce myelination oligodendrocytes. Here ,we show a new role for them- fine tuning of small axonal branches. Another one bites the neruon!

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Why is it important?

This study provides a new role for OPCs. Scientists have long wondered why there are so many of these glial cells in the brain and what do they do. We show they assist in circuit refinement by ingesting axon branches.


Team science at the Allen Institute helped make this study thanks to the production of large volume EM data sets and reconstructions.

Dr. JoAnn Buchanan
Allen Institute for Brain Science

Read the Original

This page is a summary of: Oligodendrocyte precursor cells ingest axons in the mouse neocortex, Proceedings of the National Academy of Sciences, November 2022, Proceedings of the National Academy of Sciences, DOI: 10.1073/pnas.2202580119.
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