What is it about?
Here we found that the receptor Mincle, previously known as a pattern recognition receptor of the innate immune system, plays a significant role in endocytosis. The results have revealed a new fundamental pathway of lipid endocytosis, which we call Mincle-mediated endocytosis (MiME).
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Why is it important?
Dysregulation of lipid endocytosis, a normal physiological process of cellular lipid uptake, often underlies the pathogenesis of some wide-spread diseases such as atherosclerosis, obesity, and diabetes. However, the mechanisms of lipid endocytosis are incompletely understood, and only a few such mechanisms have been discovered, limiting the available therapeutic strategies and targets in these diseases. So, our results indicate a new prospective target for the treatment of rapidly increasing in prevalence disorders of lipid metabolism
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This page is a summary of: A mechanism of self-lipid endocytosis mediated by the receptor Mincle, Proceedings of the National Academy of Sciences, July 2022, Proceedings of the National Academy of Sciences, DOI: 10.1073/pnas.2120489119.
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