What is it about?
For most mammals, olfaction plays an important role in individual recognition. The social odors secreted by individuals are complex variable mixtures that are still poorly understood. We discovered a new class of social odors for individual recognition–that is, polymorphic mitochondrial peptides that are maternally inherited and can be used to convey strain-specific information among individual mice.
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Why is it important?
Here we show that the unfamiliar (non-self) variants of non-formylated, but not N-formylated, mitochondrial peptides differing by a single amino acid residue from a familiar (self) variant function as strain-specific chemosensory cues and thus differentially induce a strain-selective pregnancy block. Our findings emphasize that the mitochondrial peptides are naturally released from a mouse and can form part of the suite of cues for the recognition of strain differences. Our findings also emphasize that pregnancy-blocking odors in the urine are maternally inherited, as evidenced by the production of reciprocal sons from two inbred strains and our test of their urine’s ability to block pregnancy. Such mitochondrial peptides that can signal individual information may be of importance in other vertebrate species, including humans.
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This page is a summary of: Maternally inherited peptides as strain-specific chemosignals, Proceedings of the National Academy of Sciences, November 2020, Proceedings of the National Academy of Sciences, DOI: 10.1073/pnas.2014712117.
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