What is it about?
We identified the major vault protein (MVP) as a key mediator between our immune system and bacterial communication - thereby advancing our understanding of how certain bacteria are able to aid our immune system to suppress tumor formation.
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Why is it important?
This work provides a unique perspective into how the immune system senses and reacts to bacterial signaling molecules through MVP, and this interaction appears to result in a decreased ability of tumor cells to gain resistance against our immune system
Perspectives
This multi-year effort to tackle a very intriguing but challenging fundamental question, shows the fruits of combining a chemical proteomics approach with in-depth cell biology to validate the identified target. It has required a tremendous amount of patience, hard work and persistence, in particular by the first authors (Josep Rayo and Rachel Gregor) who identified and validated MVP as a specific homoserine lactone receptor, and by Vladimir Kravchenko, who nailed the precise role of MVP in this complex puzzle.
Michael Meijler
Ben-Gurion University of the Negev
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This page is a summary of: Immunoediting role for major vault protein in apoptotic signaling induced by bacterial
N
-acyl homoserine lactones, Proceedings of the National Academy of Sciences, March 2021, Proceedings of the National Academy of Sciences, DOI: 10.1073/pnas.2012529118.
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