What is it about?
In this work, we demonstrate the functional significance of a large group of antitoxins on conjugative plasmids: the antitoxin PrpA acts as an novel player in the negative control of plasmid replication, by binding to the iterons in the plasmid origin that inhibits the binding of the replication initiator to the iterons.
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Why is it important?
This work shows that the antitoxin can directly regulate plasmid replication, expanding our understanding of the physiological role of TA systems.
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This page is a summary of: Conjugative plasmid-encoded toxin–antitoxin system PrpT/PrpA directly controls plasmid copy number, Proceedings of the National Academy of Sciences, January 2021, Proceedings of the National Academy of Sciences, DOI: 10.1073/pnas.2011577118.
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