What is it about?

We have shown that ErbB2 splice isoform is a driver oncogene in lung cancer

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Why is it important?

Given the the clinical utility of ErbB2 targeted therapies identifying patient that express this isoform opens up potential therapeutic interventions.


Aside from identifying the erbB2 splice isoform as a oncogenic driver, this publication has linked expression of the erbB2 pro-oncogene to lung inflammatory disease

William Muller
McGill University

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This page is a summary of: An ErbB2 splice variant lacking exon 16 drives lung carcinoma, Proceedings of the National Academy of Sciences, July 2020, Proceedings of the National Academy of Sciences, DOI: 10.1073/pnas.2007474117.
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