What is it about?
Mitogen-activated protein kinases (MAPKs) function in all eu- karyotes in signaling extracellular stimuli to intracellular responses and ultimately link them to chromatin events by targeting tran- scription factors and chromatin remodeling complexes. In plants, MAPKs play crucial roles in immunity, development, and stress responses, but so far no attempts have been made to identify phosphorylation of chromatin-associated proteins. By using a phosphoproteomic approach on MAPK mutants, we identified a number of chromatin-associated MAPK substrates and character- ize an AT-hook motif containing nuclear localized (AHL) DNA- binding protein 13 in plant immunity and demonstrate that phosphorylation regulates AHL13 protein stability and, in turn, its function in response to pathogens.
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Why is it important?
This is a first report of PAMP induced chromatin phophoproteomics in Arabidopsis. The list of phosphoproteins associated to the chromatin is a valuable resource for researchers interested in chromatin phosphoproteins.
Read the Original
This page is a summary of: Chromatin phosphoproteomics unravels a function for AT-hook motif nuclear localized protein AHL13 in PAMP-triggered immunity, Proceedings of the National Academy of Sciences, January 2021, Proceedings of the National Academy of Sciences, DOI: 10.1073/pnas.2004670118.
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