What is it about?

Mitogen-activated protein kinases (MAPKs) function in all eu- karyotes in signaling extracellular stimuli to intracellular responses and ultimately link them to chromatin events by targeting tran- scription factors and chromatin remodeling complexes. In plants, MAPKs play crucial roles in immunity, development, and stress responses, but so far no attempts have been made to identify phosphorylation of chromatin-associated proteins. By using a phosphoproteomic approach on MAPK mutants, we identified a number of chromatin-associated MAPK substrates and character- ize an AT-hook motif containing nuclear localized (AHL) DNA- binding protein 13 in plant immunity and demonstrate that phosphorylation regulates AHL13 protein stability and, in turn, its function in response to pathogens.

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Why is it important?

This is a first report of PAMP induced chromatin phophoproteomics in Arabidopsis. The list of phosphoproteins associated to the chromatin is a valuable resource for researchers interested in chromatin phosphoproteins.

Perspectives

This article is a perfect example of a research project that took years to complete with valuable contributions from several people. Hopefully, this article serves its purpose of being a valuable resource to the community of plant immunologists to unearth molecular mechanisms of plant disease.

Naganand Rayapuram
King Abdullah University of Science and Technology

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This page is a summary of: Chromatin phosphoproteomics unravels a function for AT-hook motif nuclear localized protein AHL13 in PAMP-triggered immunity, Proceedings of the National Academy of Sciences, January 2021, Proceedings of the National Academy of Sciences, DOI: 10.1073/pnas.2004670118.
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