What is it about?
We identified the anticancer compounds of the sea cucumber Holothuria scabra collected from the South Malang sea, Indonesia. From the liquid chromatography-mass spectrometry (LC-MS) analysis, it is known that the methanol extract of H. scabra contains three types of anticancer compounds, namely holothurin A, holothurin B, and holothurin B3. Based on in silico analysis, it is estimated that the holothurin compounds have target proteins, namely BCL2, HDAC1, and PTPN2, which play an essential role in the process of apoptosis, cell cycle, and suppressing tumor.
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Why is it important?
Sea cucumbers have a wide distribution and high abundance in Indonesia.The results of this study show that sea cucumber might have anticancer.
Perspectives
I hope this article raises Indonesia's natural wealth as a blessing from God for human health.
Teresa Liliana Wargasetia
Universitas Kristen Maranatha
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This page is a summary of: Anticancer potential of holothurin A, holothurin B, and holothurin B3 from the sea cucumber Holothuria scabra, January 2020, American Institute of Physics,
DOI: 10.1063/5.0002552.
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