Synthesis of Hydroxypiperidines Using 1,4-Ditosyltetrahydropyridines

  • Synlett, January 2000, Thieme Publishing Group
  • DOI: 10.1055/s-2000-6572

What is it about?

Dihydroxylation of diastereomerically pure 2-alkyl 1,4-ditosyl-1,2,3,4-tetrahydropyridines occurs with complete stereoselectivity to give the corresponding diols. Upon treatment with nucleophile-Lewis acid mixtures the derived diacetates undergo substitution reactions whose selectivity varies according to the steric bulk of the alkyl substituent.

Read Publication

The following have contributed to this page: Professor Serge THORIMBERT