What is it about?

This study evaluates the non-evidence use of partially hydrolyzed protein formula ( lactose-reduced, gentle ease, sensitive, etc..) in infants with NAS syndrome.

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Why is it important?

It has been a common practice to used partially hydrolyzed formula ( lactose-reduced formula) in many units for infants with NAS, to decrease the severity of their symptoms.


We were very motivated to study the non-evidence use of PPH formulas in infants with NAS. The change of practice in our unit allowed us the chance to do this study. In spite of being a retrospective study, we made sure to tighten our methodology to control any confounding variables. The results were interesting, however, the explanations that we suggested could explain it all.

Dr Mahdi Alsaleem
Children's Mercy Hospitals and Clinics

Read the Original

This page is a summary of: Effects of Partially Hydrolyzed Formula on Severity and Outcomes of Neonatal Abstinence Syndrome, American Journal of Perinatology, June 2019, Thieme Publishing Group,
DOI: 10.1055/s-0039-1692684.
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