What is it about?
Lithium treatment of CNS disorders can alter CSF dynamics. This happens because lithium can interfere with sodium transport at the choroid plexus, where CSF formation takes place.
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Why is it important?
Lithium, used to treat CNS diseases, alters sodium transport. Na transport by choroid plexus determines CSF dynamics. Thus, attention needs to be paid to the effects of lithium therapy on brain fluid balance.
Perspectives
The effectiveness of lithium to treat certain CNS disorders may relate to metabolic sodium balance within the brain. This Li effect includes potential effects on CSF flow among compartments in the brain and the resultant intracranial pressure.
Conrad Johanson
Brown University
Read the Original
This page is a summary of: Molecular Modeling of Cerebrospinal Fluid Dynamics in Pediatric Pseudotumor Cerebri Syndrome: Altered Sodium Transport in Choroid Plexus by Lithium Treatment, Journal of Pediatric Neurology, July 2015, Thieme Publishing Group,
DOI: 10.1055/s-0035-1555149.
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