Decarboxylative Knoevenagel-Type Reactions on Tetronamides: Synthesis of 5-Ylidene-4-Amino-2(5H)-Furanones

Luc Dechoux, Alexandre Ear, Valérie Toum, Serge Thorimbert
  • Synlett, June 2014, Thieme Publishing Group
  • DOI: 10.1055/s-0034-1378276

What is it about?

A detailed account regarding the synthesis of 5-ylidene-2(5H)-furanones is given. The key step is a decarboxylative Knoevenagel-type reaction of tetronamides with various -functionalized aldehydes. The synthesis of protected basidalin is presented.

Perspectives

Professor Serge THORIMBERT
Sorbonne Université

As recently pointed out by John Boukouvalas and coll in Journal of Organic Chemistry (2016), Basidalin has antitumor activity against leukemia as well as antibacterial properties. Our approach could be also interesting for the synthesis of other tetronamides.

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http://dx.doi.org/10.1055/s-0034-1378276

The following have contributed to this page: Professor Serge THORIMBERT