What is it about?

A detailed account regarding the synthesis of 5-ylidene-2(5H)-furanones is given. The key step is a decarboxylative Knoevenagel-type reaction of tetronamides with various -functionalized aldehydes. The synthesis of protected basidalin is presented.

Featured Image

Perspectives

As recently pointed out by John Boukouvalas and coll in Journal of Organic Chemistry (2016), Basidalin has antitumor activity against leukemia as well as antibacterial properties. Our approach could be also interesting for the synthesis of other tetronamides.

Professor Serge THORIMBERT
Sorbonne Université

Read the Original

This page is a summary of: Decarboxylative Knoevenagel-Type Reactions on Tetronamides: Synthesis of 5-Ylidene-4-Amino-2(5H)-Furanones, Synlett, June 2014, Thieme Publishing Group, DOI: 10.1055/s-0034-1378276.
You can read the full text:

Read

Contributors

The following have contributed to this page