What is it about?

A detailed account regarding the synthesis of 5-ylidene-2(5H)-furanones is given. The key step is a decarboxylative Knoevenagel-type reaction of tetronamides with various -functionalized aldehydes. The synthesis of protected basidalin is presented.

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As recently pointed out by John Boukouvalas and coll in Journal of Organic Chemistry (2016), Basidalin has antitumor activity against leukemia as well as antibacterial properties. Our approach could be also interesting for the synthesis of other tetronamides.

Professor Serge THORIMBERT
Sorbonne Université

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This page is a summary of: Decarboxylative Knoevenagel-Type Reactions on Tetronamides: Synthesis of 5-Ylidene-4-Amino-2(5H)-Furanones, Synlett, June 2014, Thieme Publishing Group, DOI: 10.1055/s-0034-1378276.
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