Propofol-based deep sedation for endoscopic ultrasonography in sick patients in Thailand

What is it about?

In a developing country, endoscopic ultrasonography (EUS) procedure is being performed at increasing rate. However, there is no recent information on deep sedation of this procedure in sick patients. The aim of this study was to evaluate the clinical efficacy of propofol-based deep sedation, and to compare between ASA physical status I-II and III-IV for EUS procedure in a teaching hospital in Thailand.

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Why is it important?

Sedation was provided for 197 patients. Of these, 156 (M, 71; mean age 56.0±14.4 years) procedures were in group C, and 41 (M, 21; mean age, 69.1±13.9 years) procedures were in group S. There were no significantly differences in gender, weight, procedure time and indication of endoscopy between the two groups. All patients in both groups were concluded with the successful completion of the procedure. The combination of fentanyl, propofol and midazolam was used in both groups. The mean dose of propofol and midazolam in both groups was not significantly different. Mean dose of fentanyl in group S was significantly lower than in group C (p<0.001). Overall adverse event in group C was significantly occurred less common than in group S. Respiratory adverse events were not statistically significantly different in both groups. Hypotension was the most cardiovascular adverse event in the two groups. All complications were easily treated, with no adverse sequelae.

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