The Influence of Enzymes on Adhesive Processes in the Abdominal Cavity

S. V. Minaev, V. S. Obozin, G. M. Barnash, A. N. Obedin
  • European Journal of Pediatric Surgery, October 2009, Thieme Publishing Group
  • DOI: 10.1055/s-0029-1241847

Adhesive Processes in the Abdominal Cavity

What is it about?

The study found that oral poly-enzyme therapy following laparotomy and abrasion of the visceral and parietal peritoneum reduces the extent of postoperative intestinal adhesions. This favorable effect can be explained by the lower levels of angiogenic agents (VEGF, bFGF) and laminin after the administration of hydrolytic enzymes.

Why is it important?

Intraperitoneal adhesions remain a common problem after abdominal surgery. However, the advent of targeted, specific agents as a directed therapy against inflammatory and neoangiogenesis raises the prospect of a new approach for anti-adhesion strategies. The mean adhesion grades of the enzyme group were significantly lower than in the control group. A comparison of the two groups showed that the expression of VEGF, bFGF and laminin in the enzyme group was lower than in the control group. Moreover, in the enzyme group the concentration of bFGF and laminin peaked on the 7th day, while in the control group the maximum concentrations peaked on day 21.


Professor Sergey Viktorovich Minaev
Stavropol State Medical University

New horizon for prevention and treatment of intraperitoneal adhesions process

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The following have contributed to this page: Professor Sergey Viktorovich Minaev