What is it about?
The epidermal growth factor (EGF) receptor (EGFR) can be transactivated by many factors including G-protein-coupled receptor agonists and cytokines. Although this EGFR transactivation reportedly requires a disintegrin and metalloproteinase (ADAM) that sheds the ectodomain of EGFR ligands, the detailed mechanisms are still unknown. This study evaluated the mechanism of interleukin (IL)-8- and IL-1beta-dependent shedding of the EGFR ligand in KATO III cells.
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Why is it important?
We have first become clear that IL-8 induces shedding of EGFR ligands through an ADAM10-dependent pathway in gastric cancer cells.
Perspectives
Inhibition of EGFR ligand shedding induced by inflammatory cytokines may lead to new strategies for prevention of cell proliferation in the gastrointestinal tract.
Dr Satoshi Tanida
Nagoya City university
Read the Original
This page is a summary of: The mechanism of cleavage of EGFR ligands induced by inflammatory cytokines in gastric cancer cells, Gastroenterology, August 2004, Elsevier,
DOI: 10.1053/j.gastro.2004.05.017.
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