Chitosan nanoparticles loaded by gentamicin

What is it about?

The aim of this study was preparation and optimization of a controlled-release delivery system to decrease the dose-dependent side effects of gentamicin. Hydrogel nanoparticles composed of a polycationic polymer (chitosan) and an inorganic polyanion (sodium tripolyphosphate), were fabricated in presence of gentamicin. An experimental design was drawn upon to determine the optimum condition of nanoparticle preparation. Various features of the nanoparticles including drug loading parameters, particle size distribution, zeta-potential and in vitro drug release profile were evaluated. Ultimately, the antimicrobial activity of the gentamicin-loaded nanoparticles was analyzed by determination of the minimum inhibitory concentration (MIC) and the potency test.

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Why is it important?

By preparation of hydrophilic nanocarrier for gentamicin, it can result in a long-circulating drug reservoir in systemic circulation to provide a steady concentration of the drug for the systemic applications while assuring the drug access to some sanctuary sites such as the brain parenchyma.