What is it about?
Synthesis of Mesoporous material using SolGel Approach is an simple and reproducible methodology; we can easily control the pore size and diameter by varying the parameters such as concentration of precursor, templating agent, reaction time and temperature, etc. Due to larger surface available for nanoparticles surface modification gaining more interest in near future for delivery biomolecules with highest payload. Cytotoxicity data specifies the dose dependent toxicity of inorganic carrier. Here we used a model drug with high loading efficiency near to 20 % than other mesoporous structures. modified surface on mesoporous structure can control release rate of drug molecule upto 24 h.
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Why is it important?
We have successfully modified the surface of mesoporous alumina which can further use for targeted drug delivery application as well as delivery of biomolecules with highest payload capacity. Another approach which may be use in future is in catalysis. On Biomedical perspective, invitro cell assay suggest, minimum toxicity levels observed in CHO cell lines.
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This page is a summary of: Development of Surface Engineered Mesoporous Alumina Nanoparticles: Drug Release Aspects and Cytotoxicity Assessment , IET Nanobiotechnology, February 2017, the Institution of Engineering and Technology (the IET),
DOI: 10.1049/iet-nbt.2016.0225.
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