What is it about?

The neuropeptide Y (NPY) Y2 receptors seem to be involved in both the metabolic processes normally activated by NPY and similar peptides, and in the cell attachment to other cells. This could be especially important in the kidney, which has very large numbers of Y2 receptors. In many types of cells, including the Chinese hamster ovary cells (CHO cells) used in this study, a large part of cell surface Y2 receptors are masked by links to membrane constituents sensitive to sulfhydryl and cholesterol perturbation.

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Why is it important?

Our findings offer some clues toward establishing a possibly dynamic involvement of the Y2 receptors in cell association and attachment.

Perspectives

An evaluation of the involvement of Y2 receptors in cell-adhesion related diseases, especially of kidney and heart, could provide new insights, possibly leading to improvements in therapy.

Prof. Steven L Parker
UTHSC Memphis

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This page is a summary of: A pool of Y2 neuropeptide Y receptors activated by modifiers of membrane sulfhydryl or cholesterol balance, European Journal of Biochemistry, April 2002, Wiley,
DOI: 10.1046/j.1432-1033.2002.02903.x.
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