Effect of potassium depletion on proximal tubule AT1 receptor localization in normal and remnant rat kidney

  • James N. Fryer, Kevin D. Burns, Masoud Ghorbani, David Z. Levine
  • Kidney International, November 2001, Elsevier
  • DOI: 10.1046/j.1523-1755.2001.00992.x

Effects of Potassium depletion on proximal tubule AT1 receptor localization

What is it about?

Both potassium depletion and renal ablation result in proximal tubule hypertrophy and the angiotensin II type 1 (AT1) receptor localization in rat proximal tubules.

Why is it important?

It is possible that the AT1 receptor intracellular distribution is modulated by potassium depletion in proximal tubular cells of 5/6 nephrectomized rats.


Dr Masoud Ghorbani
Pasteur Institute of Iran

In normal rats and those subjected to renal ablation, the immunocytochemical data provide intracellular proximal tubule AT1 receptor density after potassium depletion.

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The following have contributed to this page: Dr Masoud Ghorbani and Dr Masoud Ghorbani