What is it about?
Development of a robust purification method of the capsular polysaccharide from pneumococcus serotype 23 F, which reaches the degree of purity required for vaccine formulation and achieves a final yield adequate for industrial production.
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Why is it important?
Capsular polysaccharides from pathogenic bacteria are used as antigen of vaccines. For pneumococcus, there are two types of vaccines: 23-valent pneumococcal polysaccharide vaccine (PPV23) and 10 or 13-valent pneumococcal conjugate vaccines (PCV-10 or PCV-13). All these vaccines include polysaccharide from serotype 23F, so methods to purify this molecule from bacterial cells are extremely important.
Read the Original
This page is a summary of: Purification of capsular polysaccharide from Streptococcus pneumoniae serotype 23F by a procedure suitable for scale-up, Biotechnology and Applied Biochemistry, June 2003, Wiley, DOI: 10.1042/ba20020075.
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