Applications of 1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU) in Heterocyclic Ring Formations

What is it about?

1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU), a commercially readily available and easily handled bicyclic amidine base, is a renowned organic strong base and deprotonating agent with nucleophilic characteristics, which has gained considerable significance in organic synthesis in recent years due its selectivity (chemo-, regio-, and stereo-) and henceforth this review article provides a concise update on several types of heterocyclic rings (spiro, fused/bridged, simple) synthesized using important techniques utilizing DBU as a catalyst, base, or reactant, from June 2022 until the present.

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Why is it important?

1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU), a commercially readily available and easily handled bicyclic amidine base, is a renowned organic strong base and deprotonating agent with nucleophilic characteristics, which has gained considerable significance in organic synthesis in recent years due its selectivity (chemo-, regio-, and stereo-) and henceforth this review article provides a concise update on several types of heterocyclic rings (spiro, fused/bridged, simple) synthesized using important techniques utilizing DBU as a catalyst, base, or reactant, from June 2022 until the present.

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