Enzymatic monoesterification of symmetric diols....

What is it about?

Monoesterification of symmetric diols using lipase (CALB) enzyme.

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Why is it important?

The conventional procedure for the synthesis of a monoester from a symmetric diol is to treat the carboxylic acid with a stoichiometric amount of the diol in the presence of a mineral acid as the catalyst; however, the desired selectivity for monoester formation cannot be achieved. Through this study we have demonstrated that the lipase category of enzymes like CALB can be used for esterification reactions too, for the production of monoester derivatives with higher percent selectivity.