What is it about?
The Interaction of ZnO Nanowire in two conformations with cells in the context of morphological charges, cell growth pattern, toxicity, and cell uptake was studied in this article. Mechanism of how cells are taking up the biomolecules attached on the nanowires has also been described.
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Why is it important?
We found that different conformation of nanowires interacting very differently with cells. The two different physical conformations, vertical (VNW) or fan-shaped (FNW) nanowires have no difference in toxicity and cell growth, but cells are forming lamellipodia to wrap FNW. There is also a significant difference in endocytosis and penetration, which is also visible at the time of DNA transfection.
Perspectives
that ZnO nanowires (NWs) can efficiently deliver associated biomacromolecules, including peptides and DNA, into eukaryotic cells when in the appropriate 3-dimensional dimensional conformation with tolerable toxicity.
Dr. PRASHANT SHARMA
University of Wisconsin Madison
Read the Original
This page is a summary of: Efficient intracellular delivery of biomacromolecules employing clusters of zinc oxide nanowires, Nanoscale, January 2017, Royal Society of Chemistry,
DOI: 10.1039/c7nr05219g.
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