What is it about?
While peptide synthesis is mostly performed in toxic solvents, we propose an environmentally friendly alternative, in water, at room temperature. 2 steps can be performed in 1-pot, to make the process even greener.
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Why is it important?
The purpose is to get organic solvent out of peptide synthesis, to address health and environmental issues.
Perspectives
This method is not only a “replacement” of solvents. The hydrophobic effect created by the micellar media helps the reaction to proceed faster. In some cases, micellar catalysis succeeded when organic solvents failed.
Margery Cortes-Clerget
University of California, Santa Barbara
Read the Original
This page is a summary of: Tandem deprotection/coupling for peptide synthesis in water at room temperature, Green Chemistry, January 2017, Royal Society of Chemistry,
DOI: 10.1039/c7gc01575e.
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