What is it about?
Molecules where two rings are joined together through a single atom are known as spirocyclic compounds. A particular type, called spiroacetals, are common in biologically-active from nature. We show, for the first time, an efficient new method for making spiroacetals from simple, non-cyclic starting materials.
Why is it important?
Spiroacetals are exciting molecular scaffolds for discovering new drugs. Our method takes simple non-cyclic precursors and, by using small amounts of certain catalysts, converts them into spiroacetals with 3-dimensional structures that make them potentially useful building blocks for drug discovery.
The following have contributed to this page: Associate Professor Mark J Coster