Biomimetic Catalysis-Suzuki reaction

What is it about?

A mussel-inspired magnetically recoverable and reusable Pd nanoparticles immobilised on polydopamine coated nano-Fe3O4 was prepared and characterized by techniques such as TEM, SEM, XPS, XRD and DSC-TGA. The catalyst demonstrated remarkable activity for Suzuki-Miyaura cross-coupling reaction with a wide range of substrate scope including the less reactive aryl bromides in a benign solvent system of water/ethanol. The yields of the products were good to excellent. Moreover, the protocol provides several advantages such as tolerance to sensitive functional groups, magnetic recoverability and reusability of catalyst up to five cycles. The mechanistic studies disclosed that palladium nanoparticles undergo a dissolution and redeposition pathway during catalytic cycle. The developed methodology was successfully utilized for the synthesis of Sartan drugs’ precursor.

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Why is it important?

we have developed a magnetically retrievable, robust efficient catalytic system for the Suzuki cross-coupling reaction in which polydopamine was used as a bio-inspired benign support to immobilize the palladium nanoparticles on nano-Fe3O4. The polydopamine coating was non-degradative under the reactions conditions. The catalyst showed extremely good activity for aryl bromides, iodides, aryldiazonium salts and was inactive for aryl chlorides. The yields of the products were found to be good to excellent. The catalyst was easily recoverable and reusable up to five cycles with no loss of activity. The characterization of the reused catalyst revealed that the immobilized palladium nanoparticles catalyse the reaction by dissolution and redeposition method. Further the method was utilized for the synthesis of a Sartan drugs’ precursor.