What is it about?

We demonstrated the use of a THF-water solvent system for the LC-MS determination of five antiretrovral drugs in huma plasma. The advantages of a THF-water solvent system which have been demonstrated previously in this study include ease of de-clustering of solvent molecules from charged droplets during electrospray ionization.

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Why is it important?

This method can be used for therapeutic drug monitoring purposes for HIV/AIDS patients in hospitals

Perspectives

It is hoped that this article will be part the publications that will set the stage for the establishment of a TDM center in Botswana

Prof Kwenga Festus Sichilongo
University of Botswana

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This page is a summary of: A method employing SPE, MRM LC-MS/MS and a THF–water solvent system for the simultaneous determination of five antiretroviral drugs in human blood plasma, Analytical Methods, January 2017, Royal Society of Chemistry,
DOI: 10.1039/c6ay02442d.
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