What is it about?
It's all about metacetamol polymorph II - analogue of paracetamol drug. All information about obtaining, phys-chem characterisation, behavior under high and low temperatures. Information about relation of metacetamol I and II. Also interesting comparison to paracetamol.
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Why is it important?
Metcaetamol is a perspective drug that can substitute paracetamol. But even more interesting its polymorphism story. How metacetamol I and II are related to each other and to paracetamol polymorphs. How one can obtain and detect transformation from form I to II and visa versa. Insitu and exsitu experiments.
Perspectives
Some research can be done in the field of thermal analysis, pressure responce and crystallization issues. Even more interesting to test polymorph II on animals in terms of bioactivity and safety.
Dr Denis A. Rychkov
Novosibirsk State University, ISSC SB RAS
Read the Original
This page is a summary of: A new polymorph of metacetamol, CrystEngComm, January 2015, Royal Society of Chemistry,
DOI: 10.1039/c5ce00910c.
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