What is it about?

In this study we have describe the preparation and potential biological use and effects of linking a well-known anti-osteoporotic drug to hyaluronic acid, an abundantly available natural biopolymer in the human body through elegant chemistry. This route of generating a drug-biopolymer conjugate allows easier delivery and penetration of the drug into osteoclasts which are responsible for the destruction of bone.

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Why is it important?

This will allow the use of low concentrations of drugs that otherwise lead to a lot of side effects that are not related to the targeted tissue/organ, in this case osteoporotic bone.

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This page is a summary of: Bisphosphonate-functionalized hyaluronic acid showing selective affinity for osteoclasts as a potential treatment for osteoporosis, Biomaterials Science, January 2015, Royal Society of Chemistry,
DOI: 10.1039/c5bm00096c.
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