Heparin molecularly imprinted surfaces for the attenuation of complement activation in blood

Jenny P. Rosengren-Holmberg, Jonas Andersson, James R. Smith, Cameron Alexander, Morgan R. Alexander, Günter Tovar, Kristina N. Ekdahl, Ian A. Nicholls
  • Biomaterials Science, January 2015, Royal Society of Chemistry
  • DOI: 10.1039/c5bm00047e

Imprinting polymers with heparin for medical applications

Photo by Hush Naidoo on Unsplash

Photo by Hush Naidoo on Unsplash

What is it about?

Heparin-imprinted synthetic polymer surfaces with the ability to attenuate activation of both the complement and the coagulation system in whole blood were successfully produced. Imprinting was achieved using a template coated with heparin, a highly sulfated glycosaminoglycan known for its anticoagulant properties.

Why is it important?

The observed low thrombogenicity of this copolymer combined with the attenuation of complement activation induced by the molecular imprint offer potential for the development of self-regulating surfaces with important potential clinical applications.


Dr James R Smith
University of Portsmouth

Open access free download paper.

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