Normal and diseased meibum differ in their viscoelasticity

What is it about?

Meibum (MGS) is the major component (>93%) of tear film (TF) lipid layer. Recently it was shown that contrary to older views MGS has limited (~8%) capability to suppress the aqueous subphase evaporation. Our study suggests entirely new look to TF stability: that MGS actual role is to ensure elastic resistance of the air/tear surface to the extensional deformations involved in TF breakup with the elasticity of “diseased” MGS being compromised in comparison to the one of “healthy” MGS.

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Why is it important?

Meibomian gland dysfunction resulting in modifications of MGS composition is the leading cause (≤86% of all patients) of dry eye syndrome (DES). Caused by everyday influences like contact lens wear and extended periods in front of a PC screen, DES affects the quality of life of 10 to 30% of the human population worldwide. There is pressing need for knowledge based remedies. Our study suggests development of new treatments, focused on improving the mechanical properties of the TFLL.