What is it about?
The anticancer drug 6-thioguanine has side effects due to a photochemical reaction. But after forming the ruthenium complex, the photochemical degradation is drastically reduced. The complex functions as a more effective drug as it can be transported by transferrin, which works like a Trojan horse, into cancer cells.
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Why is it important?
If the metal complex is a better anticancer drug AND fewer side effects than 6-TG, it might be a great boon for patients suffering from ALL
Perspectives
The molecule reported here could be tested in vivo to see if they are active and if they really reduce side effects. Until then, it remains a hypothesis.
Professor Ashoka G Samuelson
Indian Institute of Science
Read the Original
This page is a summary of: Mitigating UVA light induced reactivity of 6-thioguanine through formation of a Ru(ii) half-sandwich complex, RSC Advances, January 2014, Royal Society of Chemistry,
DOI: 10.1039/c4ra02960g.
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