Addition of carbon nucleophiles to hemiaminals promoted by a Lewis acidic polyoxotungstate

Wen-Jing Xuan, Candice Botuha, Bernold Hasenknopf, Serge Thorimbert
  • Organic Chemistry Frontiers, January 2014, Royal Society of Chemistry
  • DOI: 10.1039/c4qo00193a

What is it about?

A Lewis acidic hafnium(IV) ion incorporated in a polyoxotungstate (POM/Hf) was successfully employed as recoverable catalyst in the nucleophilic addition of carbon nucleophiles, such as silyl enol ethers, silyl ketene acetals, β-diketones and β-diketoesters, to unprotected hydroxy aminal at room temperature. The corresponding α-substituted heterocycles were obtained in good yields and the recovered POM catalyst could be reused up to three times without significant loss of activity.

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The following have contributed to this page: Professor Serge THORIMBERT and Professor Bernold Hasenknopf