What is it about?
The making of tissues for regenerative medicine sometimes requires accurate positioning of cells. Here we demonstrate the usability of forces mediated by sound to manipulate cells to create complex, tartan-like patterns. This is based on creating a sound landscape using a heptagon shaped device. This device and shape allows to switch patterns easily. We test the usefulness of cells arranged by sound to create strings of cells which then guide the regeneration of injured peripheral nerve cells.
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Why is it important?
The development of acoustic cell-paterning has application in cell biology and medicine, where the ordered placement of cells within 2, and 3-dimensional defined context are important e.g. to investigate cell type specific interactions, and to deliver ways to print tissues and organs for regenerative medicine. The application which we aim to develop base on the current work are 3D structured linear arrays of gel embedded Schwann cells as a means to aid peripheral nerve regeneration.
Read the Original
This page is a summary of: Cell patterning with a heptagon acoustic tweezer – application in neurite guidance, Lab on a Chip, January 2014, Royal Society of Chemistry,
DOI: 10.1039/c4lc00436a.
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Resources
The sonic screwdriver that can turn cells tartan
Press release on publication of the heptagon/nerve paper
Grant webpage
Webpage of the EPSRC funded Sonotweezer grant (a bit defunct).
Cell Patterning with a heptagon acoustic tweezer: applications in neurite guidance PPTSX
PPT in support of the paper showing some background information
Ultrasonic manipulation explained in lay mans terms
Bruce Drinkwater & Peter Glynne-Jones explain how sound can be used as a means to manipulate the physical world in general and show some applications in biology. The video on the page was made as part of the Royal Society Summer Exhibition. Prof Bruce Drinkwater (University of Bristol) was the main PI on the EPSRC funded grant that financed the work published in LoC.
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