What is it about?
Label (with phthalimide) N-terminus of protein. Only ONE equivalent of labeling reagent is required. Reaction operates in aqueous conditions at room temperature and neutral pH.
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Why is it important?
Concept: A relay of rapid intermolecular and rate determining intramolecular step can provide opportunities to access site-selective labeling of N-terminus in a protein.
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This page is a summary of: A phthalimidation protocol that follows protein defined parameters, Chemical Communications, January 2015, Royal Society of Chemistry,
DOI: 10.1039/c4cc08503e.
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