What is it about?
We discovered that, in host-guest chemistry and using TETROL as the host compound, guests with geometries accepted as being disfavoured, such as the axial conformations of 3- and 4-methylcyclohexanone, can be exclusively included within the host cavities.
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Why is it important?
The stabilization of unusual geometries of guest molecules, such as the axial conformations of 3- and 4-methylcyclohexanone, in host crystals has not been reported before. This may be interesting for many readers who are involved in, for example, drug separation studies using crystallization techniques.
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This page is a summary of: Clathrates of TETROL: selective inclusion of methylcyclohexanones in their energetically unfavorable axial methyl conformations, Chemical Communications, January 2014, Royal Society of Chemistry,
DOI: 10.1039/c4cc06826b.
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