Exclusive inclusion of 3- and 4-methylcyclohexanone in their usually disfavoured axial conformations

What is it about?

We discovered that, in host-guest chemistry and using TETROL as the host compound, guests with geometries accepted as being disfavoured, such as the axial conformations of 3- and 4-methylcyclohexanone, can be exclusively included within the host cavities.

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Why is it important?

The stabilization of unusual geometries of guest molecules, such as the axial conformations of 3- and 4-methylcyclohexanone, in host crystals has not been reported before. This may be interesting for many readers who are involved in, for example, drug separation studies using crystallization techniques.