What is it about?
A new Cu(I) probe (OBEP-CS1), bearing an alkyl-pyridinium moiety to get complete water solubility, was synthesized. Fluorescence titrations support copper binding and high selectivity in a water solution whereas formation of aggregates was excluded by DOSY experiments. The detection capability for intracellular Cu(I), especially localized in mitochondria, was demonstrated in differentiated neuroblastoma cells by confocal microscopy.
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Why is it important?
OBEP-CS1 is the first monovalent copper probe fully soluble in water suitable for LSM imaging
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This page is a summary of: A novel fully water-soluble Cu(i) probe for fluorescence live cell imaging, Chemical Communications, May 2014, Royal Society of Chemistry,
DOI: 10.1039/c4cc02147a.
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A novel fully water-soluble Cu(I) probe for fluorescence live cell imaging
A novel fully water-soluble Cu(I) probe for fluorescence live cell imaging
A new Cu(I) probe (OBEP-CS1), bearing an alkyl-pyridinium moiety to get complete water solubility, was synthesized. Fluorescence titrations support copper binding and high selectivity in a water solution whereas formation of aggregates was excluded by DOSY experiments. The detection capability for intracellular Cu(I), especially localized in mitochondria, was demonstrated in differentiated neuroblastoma cells by confocal microscopy.
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